hugosnippert.bsky.social
We use human organoid models to study the emergence and transformation of early-stage colorectal cancer. We aim to prevent rather than cure. Research lab at Prinses Maxima Center (formerly at UMC Utrecht) & Oncode Institute https://snippertlab.nl
👤 Joined on 22 November 2024
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@hugosnippert.bsky.socialCongratulations to @landau.bsky.social, New York Genome Center Core Faculty Member, a 2026 Recipient of a Lotus Award from the Pershing Square Foundation www.nygenome.org/news-events/...
Show PostShort write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...
Show PostOrganoidNL was an excellent meeting with a range of exciting topics. A bonus was visiting Micropia, a unique museum in Amsterdam dedicated to microbes, where even living tardigrades and slime molds are on display
Show PostVery proud to share our new paper on early cancer progression, published in Nature! Beyond the science itself, this project really shows what strong interdisciplinary collaboration can achieve. I feel grateful to have been part of this amazing team. Check out our discoveries below!
Show PostExcited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
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