Alexis Barr

alexisbarr.bsky.social

21 October 2026 18:22

This was sterling work from the three first authors: @lavuillemenot.bsky.social Lucas Morales & Calin Mihai-Dragoi. Plus lots of help from all of our co-authors helping us to work out what was going on! Huge thanks to @mrc-lms.bsky.social & @cancerresearchuk.org for funding!

Alexis Barr

alexisbarr.bsky.social

21 October 2026 18:22

Our work out today in @nature.com! We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects. We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.

MRC Laboratory of Medical Sciences

mrc-lms.bsky.social

21 October 2026 16:10

Promising cancer drugs called Wee1 inhibitors have been limited by serious side effects. Researchers have discovered a previously unknown role for Wee1 that could explain why. The findings could help identify patients most likely to benefit & support development of safer, more targeted treatments.

Alexis Barr

alexisbarr.bsky.social

30 July 2026 22:13

Through a fantastic collaboration with @mariasecrier.bsky.social we show how dormant breast cancer cells occupy protected niches, presenting a therapeutic challenge. Congratulations to @cenkcelik.bsky.social for a super study

MRC Laboratory of Medical Sciences

mrc-lms.bsky.social

30 July 2026 22:13

A new study maps where dormant cancer cells hide in breast tumours: tucked into neighbourhoods of immune + support cells that may shield them from treatment. Understanding these hideouts could lead to new drug targets🧬 @mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk