James Briscoe

jamesbriscoe.bsky.social

05 October 2026 12:52

New from Andreas Sagner & co miRNAs and temporal control of neuronal fate across the vertebrate CNS Without Dgcr8, progenitors stay early and late-born neurons are lost. Rising miR-9 silences early temporal TFs to promote temporal progression www.biorxiv.org/content/10.6...

James Briscoe

jamesbriscoe.bsky.social

23 March 2026 10:13

New work by @sagnera.bsky.social & co A conserved sequence of TFs: OC2 → Pou2f2 → Pou3f1 drives chronological diversification of spinal neuron subtypes across multiple cardinal domains Spinal neuron diversity is generated by integrating spatial & temporal programs www.science.org/doi/10.1126/...

Laia Caudet-Segarra

laiacaudet.bsky.social

20 March 2026 19:01

A huge thanks to all our colleagues for their feedback and support throughout this journey! 🥂✨ #DevelopmentalBiology #Neuroscience #SpinalCord #StemCells #ScienceAdvances

Laia Caudet-Segarra

laiacaudet.bsky.social

20 March 2026 19:01

Our study demonstrates that temporal transcription factor expression across distinct cardinal domains specifies neuronal subtype identities. ➡️These findings provide evidence that spinal neuron diversity is generated through the integration of shared spatial and temporal patterning programs.

Laia Caudet-Segarra

laiacaudet.bsky.social

20 March 2026 18:59

Happy to share that our work with Kevin Sangster and Artur Kania, is finally out! @sagnera.bsky.social We investigated the mechanisms that drive the chronological diversification of spinal neuron subtypes within cardinal classes. 🧵👇 Read it here: www.science.org/doi/10.1126/...