New research from Aberdeen, now in *Nature Neuroscience* 🧠 IL-17A directly alters early human cortical development in a new 3D brain tissue model. Congratulations to the team! #Neuroscience #BrainDevelopment #Neuroinflammation #Organoids www.nature.com/articles/s41... @natureportfolio.nature.com

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New pre-print from us! We compare two iPSC-microglia protocols, and take a look at the cell autonomous and non-cell autonomous effects of MAPT mutation: www.biorxiv.org/content/10.6...

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Finally, from Christos, a study linking UK biobank data with Defra data on longitudinal, high-resolution air pollution exposure to assess the association of air pollution with #ALS risk. www.neurology.org/doi/10.1212/...

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Moving on to a study led by Emily on a TDP-43 M337V mouse embryonic stem cell-derived motor neuron model of ALS. These neurons exhibited impaired bi-directional axonal transport and reduced basal glycolysis, but occurring without evidence of TDP-43 mislocalisation. www.nature.com/articles/s41...

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Next, a methods paper led by @lizziedellar.bsky.social, demonstrating the utility of tetraspanin immunocapture for enriching extracellular vesicles #EVs from small volumes of cerebrospinal fluid for biomarker discovery. link.springer.com/article/10.1...

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