Lavisha Parab

Lavisha Parab

lavishaparab.bsky.social

Phages, microbiome, bacteria, antibiotic resistance Postdoc@LMU Munich, prev. Max Planck Inst. Evolbio @mpi-evolbio.bsky.social & IITKGP Love experimenting, science & politics she/her 💜 🏳️‍🌈 Neurodiv https://lavishaparab.github.io/ medium.com/voyagertoujours

👤 Joined on 23 August 2023

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📜 Kullanıcı Geçmişi

  • 23 Ağu 2023, 07:34
    🎉 Bluesky'e katıldı - İlk kullanıcı adı: @lavishaparab.bsky.social
  • 09 Kas 2023, 17:30
    🔄 Profil bilgileri güncellendi

❤️ Beğendiği Gönderiler

Huge thanks to my PI @vivekmutalik.bsky.social, Alexey Kazakov, @igmurray.bsky.social , and our collaborators Graham Hatfull, Michael Niederweis, Adam Deutschbauer, Katie S. Wetzel, Colin Lewis and Deborah Jacobs-Sera 🎉

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Why does it matter? 👀 Understanding how phages infect their hosts helps us design phage therapies against pathogens like M. tuberculosis and M. abscessus 💉

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- Mmpl11 is a candidate secondary receptor for 14 phages. - Lsr2 (nucleoid-associated protein) is a determinant for 31 phages.

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Key findings 🤯 - Determinant usage is largely independent of phage cluster. - Porins (Msp) are candidate primary receptors for 46 phages, the first proposed protein receptor for any mycobacteriophage. - Arabinogalactan is a candidate secondary receptor for 5 phages.

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What does it take for a mycobacteriophage to infect M. smegmatis mc² 155? 🦠🗺️ We mapped it for 70 phages using genome-wide CRISPRi. Our new preprint from the Phage Foundry is out! (phagefoundry.org) 🥳🧵 Read the preprint here: www.biorxiv.org/content/10.6...

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