Green Lab JHMI
greenlab.bsky.social
Ribosome is life. Posts by grads/postdocs, approved (sometimes) by Rachel Green. @Johns Hopkins Medical Institute https://greenlabjhmi.org
👤 Joined on 27 June 2025
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- 27 Haz 2025, 00:50
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Nature research paper: ZAK activation at the collided ribosome go.nature.com/4a9cika
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Big congrats to the entire team from the @beckmannlab.bsky.social and @greenlab.bsky.social, in particular first author Vienna!
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Despite being the driving force behind the RSR, the interaction between ZAK and ribosomes has remained elusive for years. Here, we show how ZAK is recruited to ribosomes in native as well as stress-induced conditions, and how collision-specific interactions organized on RACK1 mediate activation. 2/4
Show PostOnly in this collision geometry do the positioning of the two RACK1s allow ZAK’s RACK1-interacting motif (RIM) to engage them and enabling its SAM domains to dimerize — the key step for activation. This activation is further negatively regulated by SERBP1 competing for the RACK1 interface. 4/4
Show PostZAK is constitutively recruited to ribosomes via its RACK1-interacting helix (RIH), the eS27-pin, and the ES7-contacting patch. Upon stress, ribosome collisions generate a unique interface that enables specific contacts — the ES6-patch and the RIH-peptide. 3/4
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