Thank you to the @uclastemcell.bsky.social for their unwavering support and for this piece on our lab!

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It’s good to be in California these days. Come join us! We’ve got an open post-doc position funded by CA institute for regenerative medicine. It’s a big multi-disciplinary team science project led by @bhadurilab.bsky.social. Organoid transplants, neuro development, 2P! bri.ucla.edu/open-positio...

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This was fascinating because PPP also peaks in primary tissue at the same time as glycolysis. Was glycolysis working through the PPP? We tested this by inhibiting PPP with pharmacological inhibition, and also saw an increase in oRGs, astrocytes, and inhibitory neurons.

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Organoids love sugar! Using staining and scRNA-seq, we saw an increase in outer radial glia (oRGs), astrocytes, and inhibitory neurons. When we examined metabolite abundance in this experiment many pathways, including the pentose phosphate pathway (PPP) were downregulated.

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Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...

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