MRC Laboratory of Molecular Biology

mrclmb.ac.uk

16 September 2026 13:57

How do cells remove abnormal glycogen? Led by Matthew Yip, using mouse models, cell engineering & cryo-ET, Felix Randow's group found that RNF213 ubiquitylates aberrant glycogen to trigger autophagy. https://mrclmb.ac.uk/news-events/articles/how-cells-clear-dysfunctional-glycogen/ #LMBResearch

IonOpticks

ionopticks.com

03 August 2026 11:47

NOW PEER-REVIEWED: Emery-Corbin et al. compared 8 sample preparation methods across human serum, plasma, and rat plasma, identifying up to 2,726 human proteins and 3,767 rat proteins, with corona enrichment methods achieving the deepest coverage. Learn more: bit.ly/3RirGUI

IonOpticks

ionopticks.com

09 June 2026 09:12

NoPro-clipping: a new @komanderlab.bsky.social nanoflow LC-MS/MS workflow from @marcojochem.bsky.social et al. using an Aurora® Elite™ 15×75 column + Orbitrap Eclipse, Vanquish Neo detects ubiquitination of glycogen, glycerol & spermine in cells & tissues via targeted PRM. Learn more: bit.ly/3PYs222

Jonathan Mannion

jmannion1.bsky.social

02 May 2026 10:19

The FDA approval of vepdegestrant for ESR1-mutant ER+/HER2− advanced breast cancer marks an important milestone for PROTACs! Beyond its importance for patients, this is a landmark validation of targeted protein degradation as a therapeutic modality 👏🏻 www.fda.gov/drugs/resour...

WEHI (The Walter and Eliza Hall Institute of Medical Research)

wehi-research.bsky.social

24 April 2026 09:10

WEHI researchers have found glycogen can be directly regulated using ubiquitin, in landmark findings published in Nature. The study transforms understanding into glycogen metabolism & could lead to new treatments for diseases caused by abnormal sugar storage. www.wehi.edu.au/news/sweet-d... 🧵1/2