Journal of Human Immunity

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• Alessandro Borghesi@esibor.bsky.social03/11/2026 21:51

  As for #WNV encephalitis, severe infection by the closely related #USUV #Usutu virus is explained by IFN-I-neutralizing auto-Abs in ~half of the cases

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• Megan Cooper@macattacklab.bsky.social23/10/2026 17:19

  In the 5 years since we first reported TLR8 GOF we have learned -it is X-linked DOMINANT -mosaic or germline variants with AA 432, an antagonist binding site, most commonly affected -patients can be very sick, early recognition by deep sequencing and get them to HCT -emerging spectrum of severity

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• Turvey Lab@turveylab.bsky.social14/10/2026 13:08

  Our new IRF4 paper follows all 10 known patients with the p.T95R variant: profound combined immunodeficiency, severe infections, and progressive lung disease. HSCT can be curative, but timing matters. Thanks to our international team and the families.

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• Megan Cooper@macattacklab.bsky.social25/09/2026 13:26

  A pleasure to work with Ofer Zimmerman & @washumedicine.bsky.social heme to make the diagnosis in this adult woman who had symptoms for two decades. TLR8 GOF is X linked DOMINANT -males & females. Our original cohorts were younger (I’m a pediatrician!) there are more older adults out there

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• Manish Butte@manishbutte.bsky.social01/09/2026 13:28

  We all know recurrent infections is a hallmark of many primary immunodeficiencies, but what really is "recurrent"? In the electronic health record, recurrence is far from obvious. Aaron figured out a way to tease recurrence from the data. The impact is finding immune deficiency patients sooner. #IEI

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