Osterman Ilya

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• Bohdana Hurieva🇺🇦@bhurieva.bsky.social03-11-2026 20:57

  Thanks Ilya!😊

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• bioRxiv Microbiology@biorxiv-microbiol.bsky.social03-11-2026 20:08

  DarHTG is a tripartite phage defence system for purine DNA base ADP-ribosylation https://www.biorxiv.org/content/10.64898/2026.11.02.763450v1

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• Sorek Lab@soreklab.bsky.social03-11-2026 20:06

  We posted an update to our preprint from April, where we showed that the TIR domain of TLR4 is an NAD-processing enzyme: Together with the Hornung lab, we now show that the TIR catalytic activity is essential for TLR4 signaling in human cells www.biorxiv.org/content/10.6...

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• Bohdana Hurieva🇺🇦@bhurieva.bsky.social03-11-2026 19:59

  The catalytic residue of the TLR4 TIR is required for immune signaling in human cells. In our updated preprint with @v-hornung.bsky.social’s lab, we show that a single point mutation in this site abolishes the LPS response in macrophages 🧵 www.biorxiv.org/content/10.6...

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• Landon Getz@landongetz.bsky.social02-11-2026 22:28

  Forgot to share last week: the molecular control of bacterial immunity review I wrote with @themaxwelllab.bsky.social and Sam Fairburn is out! In it, we cover sensing, activation, and effector mechanisms, as well as phage counter-defence strategies. www.nature.com/articles/s41...

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