Frederik Hermann
@frederikhermann.com did:plc:s6jozcjzatrajd45xocfs47c
Senior Director of Marketing at 23andMe, 4 exits including one IPO, focused on global marketing, growth and demand generation in #DTC and #B2B. Please visit https://www.frederikhermann.com for more information or to get in touch.
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Frederik Hermann (@frederikhermann.com) ist seit 3 September 2024 auf Bluesky. Das Konto hat 23 Follower, folgt 45 Konten und hat 5 Posts veröffentlicht.
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An inherited genetic mutation may increase lung cancer risk among people who have never smoked, according to a new Science study. Learn more in this week’s issue: https://scim.ag/3Td6qQV
Post anzeigenHuge congratulations to the incredible 23andMe Research and Dana-Farber teams for getting this over the finish line. And *as always*, a massive thank you to the 23andMe participants who make this research possible!
Post anzeigenThis paper is a beautiful example of what a large direct-to-consumer cohort makes possible: T790M is rare enough that its risk had never been reliably estimated. Its origins and distribution may support geographically targeted testing. www.science.org/doi/10.1126/...
Post anzeigenIn all carriers, the variant was found on a European-ancestry haplotype. The team to estimated TMRCA: ~1707 for British-ancestry carriers, predating many colonial voyages, so the mutation likely arose in Europe.
Post anzeigenThe team then traced the variant origins. An IBD analysis against 3.45M participants with grandparent birth coordinates put the peak relatedness to carriers in northern Alabama/southern Tennessee. Carrier frequency: 1 in 2,078 in AL/MS/TN vs 1 in 12,821 US-wide; a 6X enrichment.
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