Alisia Fadini
@alisiafadini.bsky.social did:plc:njgjuave7loexmk6jceth66n
Researcher. Learning biomolecular function and dynamics beyond the single-structure frontier @Columbia University
Bei Bluesky seit
- Follower
- 424
- Folgt
- 247
- Posts
- 51
- Tage in Ranglisten
- 0
Zusammenfassung
Alisia Fadini (@alisiafadini.bsky.social) ist seit 12 Dezember 2024 auf Bluesky. Das Konto hat 424 Follower, folgt 247 Konten und hat 51 Posts veröffentlicht.
Ranglisten-Platzierungen
Die besten Tage, an denen Posts dieses Kontos in Debyas Tagesliste kamen.
Dieses Konto war noch in keiner Tagesrangliste.
Zuletzt gelikte Posts
Öffentliche Likes aus dem Bluesky-Netzwerk.
The #OpenBind Blind Challenge is now LIVE! Can your model predict ligand binding poses for 414 compounds against the Zika virus NS2B-NS3 protease? Join the challenge, submit predictions and see how your method performs. https://loom.ly/1aQdU3U #AIforScience #DrugDiscovery #OpenBind
Post anzeigen5/5 So rather than asking whether a dataset “contains an ensemble,” we suggest thinking in terms of a new research frontier: ** ensemble resolution ** Specifically, what differences between distributions can your data distinguish? What do you think? Let us know!
Post anzeigen4/5 Then comes processing. Cryo-EM preserves molecule-to-molecule variation, but filtering, alignment, classification, and reconstruction can remove or compress that information. Crucially, a reconstruction can gain spatial resolution while losing ensemble information.
Post anzeigen3/5 Single-particle measurements preserve variation more directly. But neither case gives you the ensemble for free. Averaged data constrain only certain features of the distribution. In single-particle, noise, nuisance variables, and finite sampling interfere.
Post anzeigen2/5 Different experiments encode the distributions in very different ways. An averaged measurement like X-ray diffraction can still contain a distribution: averaging observables is not the same as averaging structures.
Post anzeigen
Blockierte Konten
Blockierungen sind auf Bluesky öffentlich.
Dieses Konto blockiert niemanden.