Cornelius Gati
@gati.bsky.social did:plc:kmmf4qc2ffnrbignk7b7qeax
Associate Professor at USC. Structural biology and pharmacology with a focus on GPCRs. 💊 🧪 https://www.gati-lab.com https://scholar.google.com/citations?user=5t80YUAAAAAJ&hl=en
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Cornelius Gati (@gati.bsky.social) ist seit 31 Oktober 2023 auf Bluesky. Das Konto hat 2.501 Follower, folgt 1.005 Konten und hat 99 Posts veröffentlicht.
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Check out an epic new study by star student Matt Howard 🤩!!! We've been working on this for many years and we generate a ridiculous amount of data to address a classic gpcr question using the opioid receptor as a model - how do ligands binding to the same site activate receptors to varying degrees!
Post anzeigen🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10
Post anzeigenCheck out our latest paper on efficacy photoswitches that can locally light up opioid receptors, thus avoiding unwanted central and peripheral side effects (respiratory depression, constipation). www.cell.com/cell/fulltex...
Post anzeigenExciting work! Congratulations!
Post anzeigenOur new investigation examining how #SBI-553 a biased modulator of NTSR1 alters motivated feeding and NST potentiation of inhibitory transmission in the extended amygdala is now online! www.sciencedirect.com/science/arti...
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