Milan Savani
@milansavani.com did:plc:gw2t3p6mm5omibcmuqa7c7e4
Medical student at UT Southwestern. PhD from the McBrayer Lab at the Children's Research Institute @ UTSW. | nitrogen metabolism in glioma | he/him
Bei Bluesky seit
- Follower
- 66
- Folgt
- 116
- Posts
- 16
- Tage in Ranglisten
- 0
Zusammenfassung
Milan Savani (@milansavani.com) ist seit 19 November 2023 auf Bluesky. Das Konto hat 66 Follower, folgt 116 Konten und hat 16 Posts veröffentlicht.
Ranglisten-Platzierungen
Die besten Tage, an denen Posts dieses Kontos in Debyas Tagesliste kamen.
Dieses Konto war noch in keiner Tagesrangliste.
Zuletzt gelikte Posts
Öffentliche Likes aus dem Bluesky-Netzwerk.
11/ In addition to first authors Kalil Abdullah, Kenji Miki, Charley Edgar, Shuangcheng Wu & @yixiao.bsky.social, other collaborators included @rjdlab.bsky.social, @michellemonje.bsky.social, Kim Huber, Jay Gibson, @herveyjumper.bsky.social, Simon Chamberland, @mathews-tom.bsky.social & many others.
Post anzeigen10/ This work connects cancer metabolism & cancer neuroscience. Drawing on a rare metabolic disease, it shows how gliomas rewire creatine metabolism to produce GAA and increase neuronal activity, which drives tumor growth. These findings identify GAA as a potential targetable vulnerability of HGGs.
Post anzeigen9/ The link to GAMT deficiency suggested another way to test the model. Dietary arginine restriction plus ornithine supplementation lowers GAA and reduces seizures in patients with GAMT deficiency. Applying this diet to glioma-bearing mice reduced tumoral GAA levels and attenuated glioma growth.
Post anzeigen8/ Is GAA-driven neuronal hyperexcitability required for tumor growth? AGAT knockout depleted GAA without impairing glioma growth in monoculture. Yet, in mouse brain, it reduced neuronal activity and prolonged survival, indicating that GAA’s oncogenic effects depend on the neural microenvironment.
Post anzeigen7/ The answer lies in neuronal chloride homeostasis. Neurons near HGG cells have elevated intracellular Cl-, partly due to reduced KCC2 expression, making GABAA receptor signaling depolarizing. Indeed, GAA increased neuronal firing in HGG-infiltrated brain, but not in the contralateral hemisphere.
Post anzeigen
Blockierte Konten
Blockierungen sind auf Bluesky öffentlich.
Dieses Konto blockiert niemanden.