David Vilchez
thevilchezlab.bsky.social
Biologist, Professor at CECAD, University of Cologne. We study aging, age-related diseases, stem cell biology and proteostasis. http://www.davidvilchezlab.com/
👤 Joined on 13 September 2023
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- 13 Eyl 2023, 11:10
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
@thevilchezlab.bsky.social - 10 Kas 2023, 04:02
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What mechanisms underlie the benefits of moderately cold temperatures, associated w/ delayed aging? 🧪 In Nature, David Vilchez et al. identify a metabolite-driven, multi-tissue signaling system that links cold temperature to enhanced longevity & proteostasis in C. elegans: https://ow.ly/eZ1t5101tno
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A paper in Nature reports that moderate cold activates a muscle-derived BH2/BH4/tyrosine pathway that improves proteostasis and lifespan in C. elegans. Human-cell data suggest conserved proteostasis effects, but longevity effects have not been tested beyond worms.🧪 www.nature.com/articles/s41...
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Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis go.nature.com/4e1pmJK
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In worms, cold raised muscle production of a metabolite, BH2, that other tissues turn into BH4, extending lifespan and curbing disease-related protein aggregation. More BH2 from muscle alone did it at normal temperatures too. #aging #longevity @thevilchezlab.bsky.social @frezzalab.bsky.social
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🚨 Publication Alert 🚨 #CRC1678 teamwork! New @nature.com paper spearheaded by @thevilchezlab.bsky.social in collaboration with Thorsten Hoppe reveals a cold‑induced BH2–BH4 pathway that boosts proteostasis and longevity. Great work! Congrats to everyone involved 🥳 👉 doi.org/10.1038/s415...
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